Strongest Digestive Enzymes: In-Depth Analysis

We have researched 13 digestive enzymes for you.

Finding the right supplement to enhance gastrointestinal function can be a game-changer for those struggling with digestive issues. With an array of choices on the market, it can be overwhelming to determine which ones pack the most punch. That's why we've scoured the options available to bring you a lineup of powerhouse formulas designed to support your digestive system.

These top picks have been carefully selected based on their potency, ingredient quality, and user feedback. With a focus on the strongest blends of digestive enzymes, we aim to help you make an informed choice that could help you find the relief you seek and improve your overall gut health. Here's our guide to some of the most effective enzyme supplements out there.
To simplify the price comparison, we determine the prices for the individual articles on Amazon, Ebay and other shops and link the offers via partner links where applicable. This means that we receive a commission if you buy something that we recommend - the price does not change for you.

What to Look for in Strongest Digestive Enzymes

Important criteria

  • Full spectrum of digestive enzymes
  • Potency and activity level of the enzymes
  • Purity and quality of ingredients
  • Specific enzymes for problem foods (e.g., lactase for lactose intolerance)
  • Non-GMO certification
  • Vegan or vegetarian-friendly, if required

1.) Enzyme Concentration and Variety

When selecting the strongest digestive enzymes, consider the concentration and variety of enzymes included in the product. A high-quality supplement should contain a potent mix of different enzymes suited to breaking down various types of food, such as proteases for proteins, lipases for fats, and amylases for carbohydrates. The concentrations of these enzymes should be high enough to have a therapeutic effect. Look for specific activity units like HUT (Hemoglobin Units Tyrosine base) for proteases or FCCLU (Food Chemical Codex Lipase Units) for lipases, which indicate enzyme potency.

2.) Source and Quality of Ingredients

The source of the enzymes matters as some are derived from animals (pancreatin from pigs or cows), while others are from microbial or plant sources (like bromelain from pineapples or papain from papayas). If you're vegetarian or vegan, opt for non-animal sources. Additionally, the purity and quality of the enzymes are crucial for efficacy and safety. Choose supplements that have undergone rigorous quality control testing and are free from contaminants or unnecessary fillers.

3.) Delivery Mechanism and Enteric Coating

The delivery mechanism is another important aspect. Enzymes can be denatured by stomach acid, so look for products with an enteric coating that ensures the enzymes are protected until they reach the intestines where they are needed. Some products use capsule forms that resist stomach acid or other means to ensure the enzymes maintain their activity until they are in the digestive tract.

4.) Potential Allergens and Fillers

Be aware of potential allergens or fillers that could cause adverse reactions, especially if you have allergies or food sensitivities. Check the label for common allergens like gluten, soy, dairy, and eggs. Opt for a product that is labeled as hypoallergenic. Furthermore, avoid unnecessary fillers and additives that might be used to bulk up the product or extend its shelf life, as they do not contribute to the effectiveness of the enzymes and might cause unwanted side effects.

The Strongest Digestive Enzymes of our Choice

Our Pick
Zenwise Health Digestive Enzymes
Zenwise Health Digestive Enzymes
Type/Color: Off-white Size: 180 Count (Pack of 1)
  • Digestive Enzymes with Pre & Probiotics Supplements: Helps relieve occasional bloating, gas, and discomfort.
  • Complete Gut Wellness: Replenishes digestive enzymes and promotes regularity and immune health.
  • Clinically Proven De111 Probiotic: Works in the small intestine and supports nutrient absorption and immune system.
  • Botanical Bounty: Turmeric, Ginger, Green Papaya, Inulin, Apple Pectin, Bladderwrack, Fennel, and Wakame aid gut health.
  • 180 Serving Supply: Includes 180 capsules for digestive support.
  • Suggested Use: Take 1 capsule before each meal.
$ 37.97 *
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2
Enzymedica Digest Gold + ATPro
Enzymedica Digest Gold + ATPro
Model: P38572 Type/Color: Natural Size: 90 Count (Pack of 1)
  • Savor dishes worry-free with our digestive enzyme blend
  • ATPro Blend boosts energy and helps fuel your body
  • Thera-blend enzymes offer optimal activity throughout digestion
  • Just 1 capsule daily breaks down fat, protein, and carbs
  • No gluten, milk, soy, or artificial ingredients
  • Enzymedica products use natural ingredients
  • We create quality products while supporting well-being
$ 40.12 *
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3
Pure Encapsulations Digestive Enzymes Ultra
Pure Encapsulations Digestive Enzymes Ultra
Size: 90 Count (Pack of 1)
  • Nutrient Absorption: Vegetarian enzymes support nutrient absorption
  • Supports Digestion: Aids in breaking down various food components
  • Digestive Enzymes: Wide pH range for optimal enzyme activity
  • Dairy Enzyme Blend: Facilitates digestion of dairy and certain carbs
  • Pure Difference: Free from allergens, artificial ingredients, and GMOs
$ 36.20 *
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Price Pick
MRM Nutrition Digest-All ®
MRM Nutrition Digest-All ®
Model: 31013 Type/Color: Purple Size: 100 Count (Pack of 1)
  • Added digestive support for issues related to aging or large meals.
  • Full spectrum of enzymes for faster and more effective nutrient digestion.
  • Includes Digest-All Herbal Blend with ginger, peppermint, and triphala.
  • Take 2 capsules before each meal or as directed by healthcare provider.
  • Certified Gluten-Free and 100% vegetarian.
$ 17.59 *
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5
MaryRuth Organics Ultra Digestive Enzymes Capsules
MaryRuth Organics Ultra Digestive Enzymes Capsules
Size: 60 Count (Pack of 1)
  • Enhances digestion with Ultra Digestive Food Enzymes
  • Formulated to support digestion and reduce bloating
  • Helps digest proteins, carbohydrates, fiber, fat, and lactose
  • Includes enzymes to relieve occasional gas and bloating
  • Vegan formula with a blend of essential enzymes and vitamins
  • Easy absorption, 60 capsules lasting 1-2 months
  • For men and women, take 1 capsule prior to each meal
  • Suitable for most lifestyles, Non-GMO, Dairy Free, Gluten Free
  • Contains corn-derived Maltodextrin as an ingredient
$ 24.90 *
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6
Source Naturals Essential Enzymes 500mg Bio-Aligned Multiple
Source Naturals Essential Enzymes 500mg Bio-Aligned Multiple
Model: SN0660 Size: 120 Count (Pack of 1)
  • Digestive enzymes transform food into nutrition.
  • Suggested Use: 1 capsule at each meal.
  • No yeast, dairy, egg, gluten, corn, soy, or wheat.
  • No sugar, starch, preservatives, or artificial additives.
  • Source Naturals established in 1982, trusted for 40+ years.
  • Manufactured in the USA under FDA cGMPs.
$ 14.12 *
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7
NatureBell Digestive Enzymes with Prebiotics
NatureBell Digestive Enzymes with Prebiotics
Size: 240 Count (Pack of 1)
  • Digestive Enzyme and Prebiotic complex
  • 240 veggie capsules per bottle
  • 1 capsule daily for an 8-month supply
  • Max strength natural proprietary blend
  • Delivers 400mg total per serving
  • 20 enzymes and 5 prebiotics included
  • Promotes digestion and nutrient absorption
  • Supports bloating and overall gut health
  • Balances gut flora with unique combination
  • Authentic non-GMO digestive enzyme supplement
  • Contains pure ingredients, free of allergens
  • 3rd party lab tested for safety and potency
$ 13.95 *
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8
Double Wood Supplements Digestive Enzymes
Double Wood Supplements Digestive Enzymes
Size: 180 Count (Pack of 1)
  • Contains all 10 essential digestive enzymes
  • Includes top 3 pancreatic enzymes
  • VitaZyme Digestive Aid trademark by Double Wood
  • Aids digestion and supports digestive health
  • Digests proteins, fats, and carbohydrates
  • Manufactured and safety tested in USA
  • Non-GMO and gluten free
$ 18.95 *
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9
Garden of Life Dr Formulated Digestive Enzymes with Papain
Garden of Life Dr Formulated Digestive Enzymes with Papain
Model: 102428 Size: 90 Count (Pack of 1)
  • Organic Digest with 29 Certified Organic fruits and veggies
  • Contains blend of 13 powerful digestive enzymes
  • Enzymes help with digestion of proteins, fats, carbs
  • Prebiotic fiber support for good gut bacteria
  • Made using Clean Tablet Technology for nutrient absorption
  • Tropical flavored, shelf stable tablet for on-the-go
  • Chew 1 tablet after meal or snack for benefits
  • Dr. Formulated by David Perlmutter, MD
  • Certified Non-GMO, Gluten-Free, Vegan, Carbon Neutral
  • Made in the USA with no dairy, soy, gluten, peanuts, or tree nuts
$ 27.19 *
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10
Vital Nutrients Pancreatic Enzymes 1000mg (Full Strength)
Vital Nutrients Pancreatic Enzymes 1000mg (Full Strength)
Size: 90 Count (Pack of 1)
  • Contains amylase, lipase & protease
  • Supports better absorption & digestion
  • Formula free from gluten, dairy, soy, etc.
  • Every ingredient & batch tested above standard
  • Committed to producing premium quality supplements
$ 39.90 *
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11
Physician's CHOICE Digestive Enzymes
Physician's CHOICE Digestive Enzymes
Size: 30 Count (Pack of 1)
  • Contains 16 beneficial enzymes for diverse diets.
  • Includes SBO Probiotics & Prebiotics for digestion aid.
  • Powerful digestive enzymes break down food effectively.
  • Prebiotics & probiotics promote digestive function synergistically.
  • Formulated with 3 soil-based probiotic strains for survival.
  • Organic Prebiotics fuel growth of healthy gut bacteria.
  • Crafted based on scientific research with expert review.
  • 3rd-party tested for purity and potency assurance.
$ 12.97 *
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12
Global Healing Ultimate Enzymes
Global Healing Ultimate Enzymes
Size: 120 Count (Pack of 1)
$ 49.95 *
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13
Doctor's BEST Digestive Enzymes Non-GMO Vegetarian Gluten Free
Doctor's BEST Digestive Enzymes Non-GMO Vegetarian Gluten Free
Size: 90 Count (Pack of 1)
  • Full-spectrum digestive enzyme blend supports digestion.
  • Enzymes aid in digesting fats, proteins, and carbohydrates.
  • Supplies alpha-galactosidase and beta-glucanase for breaking down vegetables, beans, and grains.
  • Helps with digestion of sugars through enzymes like glucoamylase and invertase.
  • Contains friendly probiotic bacteria for optimal intestinal health.
  • Formulated with enzymes to optimize breakdown of fats, carbs, and protein.
  • Lipase improves fat utilization for better fat digestion.
  • Enzyme supplements reduce need for body's enzyme production.
  • Free up body's energy for maintaining overall health.
  • Non-GMO, gluten-free, soy-free, and vegetarian.
  • Product may get warm during delivery in summer.
  • Amazon follows manufacturers' recommendations for storage and shipping.
$ 21.44 *
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* All prices incl. VAT, plus shipping if applicable. Prices, delivery times and costs may change in the meantime. The selection of products was made independently of the manufacturer and without any claim to completeness. All links to products are external partner links through which we may receive compensation. All information without guarantee.

Top Picks for Potent Digestive Enzymes

For the Health-Conscious Shopper
Discerning customers seeking to maintain their well-being will find a selection that prioritizes high-potency blends. These options are chosen to complement a mindful lifestyle without overwhelming you with choices.
Budget-Friendly Enzymes
If you're looking for a product that balances efficacy and affordability, our curated list provides excellent options. Explore a range that ensures you don't compromise on quality while adhering to your budget.
Premium Digestive Aids
For those who only want the most exclusive products, our selection represents the pinnacle of sophistication. Delve into a collection where each choice echoes a commitment to premium wellness solutions.
Travel-Sized Options
Adventurers and on-the-go individuals will be pleased by our travel-friendly picks. Compact yet powerful, these enzymes are designed to support your digestive system wherever your journey takes you.

Questions You Might Ask

Digestive enzymes are proteins that aid in the breakdown of food into nutrients that can be absorbed by the body. They are crucial for proper digestion and are naturally produced by the body, but can also be taken in supplement form.
A person might need a digestive enzyme supplement if they have a deficiency or insufficiency of natural digestive enzymes, which can lead to digestive disorders such as lactose intolerance, bloating, gas, or indigestion. Supplementing can help improve digestion and nutrient absorption.
When choosing a supplement, look for one that includes a variety of enzymes to match the foods you eat, such as protease for proteins, lipase for fats, and amylase for carbohydrates. Consider the potency of the enzymes, and whether the product is free from allergens if you have sensitivities.
Some people may experience side effects such as stomach pain, nausea, diarrhea, or allergic reactions. It's important to follow the dosage instructions and talk to a healthcare provider if you have any concerns or experience adverse effects.

Currently Active Poll

How to Choose the Strongest Digestive Enzymes

Are you in the market for a digestive aide that can handle tough foods with ease? Strong digestive enzymes may be just what you need. But with so many options available, it's crucial to know how to pick the right one. This guide is designed to empower you with knowledge so you can select the strongest digestive enzymes that will work best for your body's unique needs.

Understanding Digestive Enzymes

Digestive enzymes are naturally occurring proteins that help break down food into nutrients your body can absorb. They play a critical role in digestion, working on different types of foods such as proteins, carbohydrates, and fats. There are three main types of digestive enzymes: proteases for protein, lipases for fat, and amylases for carbs.
Unfortunately, not everyone produces these enzymes in sufficient amounts, which is where supplementation comes in. Taking the right enzyme supplement can help your body process food more efficiently, reducing digestive discomfort, such as bloating and gas, and improving overall health.
Before buying, it’s vital to recognize the symptoms you're experiencing and relate them to the types of food you might need help with. For instance, if you struggle with meat and dairy, a product with a high protease content is advisable.

Potency and Strength

When scouring the shelves for a strong digestive enzyme, it's important to consider potency, often listed as activity units on the label. These units measure an enzyme's power to break down food, not just the weight of the enzyme itself. Good quality supplements will list enzymes' potency using units like FCC (Food Chemical Codex) or HUT (Hemoglobin Unit Tyrosine base).
The strongest digestive enzyme supplements will have a high potency count, which means they contain more active units capable of digesting food effectively. However, don't just go for the highest number you find; the best enzyme for you is the one that fits your specific digestive needs.
Keep in mind, too, that sometimes a blend of enzymes (full-spectrum) designed for all types of macronutrients can offer a more comprehensive solution, particularly if you have multiple food sensitivities.

Ingredients and Sources

It's critical to inspect the source of the enzymes in the supplements you're considering. Enzymes can be derived from animals (usually labeled as pancreatin), plants (such as bromelain from pineapple), or produced by fermentation using microbes. Individuals with dietary restrictions or allergies should pay close attention to the source to avoid adverse reactions.
Moreover, look out for additional ingredients that might enhance or adversely affect the supplement's action, like fillers, preservatives, or allergens. Ideally, you'll want to choose a product that's pure and free from any components that don't serve your health goals.
Also, consider if the product is tailored to special diets such as vegan, kosher, or halal, and check for certifications that may align with your personal values and health needs.

Delivery Forms and Usage

Digestive enzymes come in various delivery methods, including capsules, tablets, powders, and even chewable forms. Capsules are generally preferred as they tend to protect enzymes from stomach acid, thereby preserving their potency until they reach the small intestine where they're needed.
Moreover, the timing of when you take your enzymes is an essential factor to consider. Some enzymes should be taken right before a meal to work effectively, while others may have different recommendations. Always follow the instructions provided by the manufacturer for optimal results.
Additionally, while considering the form, take into account your own preferences and lifestyle. If you have difficulty swallowing pills, for example, a chewable or powder form might be more suitable for you.

Consulting with Health Professionals

Although digestive enzymes are available over the counter, it's a good practice to consult with a healthcare provider or a dietitian before starting any new supplement regimen. They can provide personalized advice based on your health history and dietary needs, ensuring that you choose the strongest and most effective product.
Your healthcare provider can also help you understand any interactions that digestive enzymes may have with other medications you're taking. Plus, they might conduct tests to determine if you have a specific enzyme deficiency, guiding you to an appropriate supplement choice.
Remember, the ultimate goal is to support your digestive health without causing additional issues. Therefore, a consultation is a step worth taking for peace of mind and targeted results.

Hands-on Reviews and Recommendations from Discussion-Boards

The following section presents a curated collection of resources pertaining to the strongest digestive enzymes available for those seeking well-informed guidance. Our selection encompasses a variety of formats to suit different preferences, including thorough test reports, authoritative reviews, insightful discussions from expert forums, and informative video content. For ease of navigation, we have organized these resources into four distinct categories: reviews, forum posts, Reddit discussions, and videos. These links have been chosen for their relevance and reliability to assist you in making an informed decision.
May 2, 2021 — Simple lifestyle changes can alleviate many digestive issues. Consumer Reports shows you how to get relief from gas, heartburn, ...
Read more | Helpful?
Jan 19, 2020 — Adaptogens help to tame our stress response over an extended period of time, while nervines, such as chamomile, lemonbalm, passionflower and ...
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Nov 26, 2018 — Gut bacteria are essential for health, and many people take supplements to replenish them. Should you? Consumer Reports explains the risks...
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May 3, 2023 — “This may be because we're making less of certain enzymes, so it's harder to digest them.” Be fiber-wise. Fiber is a boon for overall health ...
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Why do you feel the need for a digestive enzyme? Bloating or GI issues? I'd rather look at your food choices causing problems. I will say, ...
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Betaine HCL, Pepsin and Gentian herb are all good. Dr's Best sells all 3 combined in one pill.
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What supplements have worked best for you, and what do you recommend? Thanks! Upvote 10
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Availability of Enzyme supplements will depend on your country, here's some links.
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Pancreatic enzymes are lipase (to digest fat) ... For me kyolic digestive enzymes with probiotics, Dr best digestive enzymes were quite effective.
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9 Best Digestive Enzymes 2018 - YouTube
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