Best Runes&Souls in Isaac - Round 10

by Andreas ·

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Rune of Algiz (invincibility for 20 seconds)

Rune of Ansuz (Reveals the map except Ultra Secret Rooms)

Rune of Dagaz (Removes curses except Curse of the Labyrinth + grants 1 Soul Heart)

Rune of Ehwaz (Spawns a trapdoor to the next floor, or a Crawl Space if used on special tiles)

Rune of Jera (Clones all pickups and chests in the room)

Rune of Perthro (Rerolls item pedestals, just like the D6)

Black Rune (Necronomicon + consumes item pedestals into stat upgrades)

Soul of Apollyon (Spawns 15 random locusts)

Soul of Azazel (Uses Mega Blast for 7.5 seconds)

Soul of Bethany (Spawns 6 random wisps)

Soul of Cain (Opens all doors in the room + spawns Red Rooms on all possible walls in the room)

Soul of Eden (D6 + D20 effect. Rerolled items are from random item pools)

Soul of Eve (Spawns 14 Dead Bird for the current room)

Soul of Isaac (Makes item pedestals cycle between 2 options)

Soul of Jacob and Esau (Spawns a temporary Esau for the current room. Esau gets the equal amount of items as the player)

Soul of Lilith (Spawns a permanent familiar)

Soul of The Forgotten (Spawns a temporary Forgotten for the current room with high damage)

Soul of the Keeper (Spawns between 1 and 25 random coins)

Soul of The Lost (Turns Isaac into The Lost for the current room, with all of The Lost's benifits)

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